Thermo Fisher Scientific Desmoglein 3 Monoclonal Antibody (3G133)
Desmoglein 3 단클론 항체로 인간 Dsg3에 특이적 결합. Western blot, IHC, ICC, IP 등 다양한 응용에 적합. Desmoglein 1 및 2와 교차 반응 없음. A431 세포를 양성 대조로 사용 가능. 연구용으로만 사용.
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Thermo Fisher Scientific Desmoglein 3 Monoclonal Antibody (3G133)
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–3 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 20–50 µg/mL |
| Immunocytochemistry (ICC/IF) | Assay-dependent |
| Immunoprecipitation (IP) | 5–10 µg/mL |
Product Specifications
| Property | Description |
|---|---|
| Host/Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 3G133 |
| Immunogen | Recombinant fragment (Human Desmoglein 3 extracellular domain) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2093599 |
Product Specific Information
- Does not cross-react with Desmoglein 1 or 2.
- A431 cells can be used as a positive control for this antibody.
Target Information
Desmoglein 3 (Dsg3), also known as Cadherin family member 6 (CDHF6), is a member of the desmosomal cadherin family and plays a critical role in cell-cell adhesion. It is predominantly expressed in stratified squamous epithelium, including the skin, oral mucosa, and esophagus.
Desmoglein 3 has been characterized as the auto-antigen of pemphigus vulgaris (PV), a life-threatening autoimmune disease. Binding of anti-Desmoglein 3 autoantibodies causes loss of cell-cell adhesion, clinically manifesting as blisters on the skin and oral mucosa, and histologically as suprabasilar acantholysis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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