Thermo Fisher Scientific Cardiac Troponin I Monoclonal Antibody (415)

Applications

Western Blot (WB)

• Tested Dilution: Assay-dependent

Immunohistochemistry (IHC)

• Tested Dilution: Assay-dependent

Immunoprecipitation (IP)

• Tested Dilution: Assay-dependent

Affinity Purification (AP)

• Tested Dilution: Assay-dependent

Product Specifications

Product Specific Information

MA1-91566 detects Cardiac Troponin I from human samples.

Target Information

Cardiac Troponin I (Cardiac-specific troponin I, TnI, Troponin I) is an integral inhibitory protein in cardiac muscle that exists as part of a complex with troponin C (TnC) and troponin T (TnT). The TnT subunit of troponin binds to tropomyosin to form a troponin–tropomyosin complex, anchored in place by the binding of TnI to actin within muscle thin filaments. Structural change resulting from the binding of calcium to specific sites on the regulatory TnC subunit releases the inhibitory region of TnI from actin, enabling the attachment of the molecular motor protein myosin, allowing for muscle contraction and movement.

Measurement of blood TnI and TnT levels is an important diagnostic indicator of heart muscle damage and can be used to differentiate between angina and myocardial infarction in patients with chest pain. Cardiac Troponin I has also been shown to inhibit angiogenesis in vivo and in vitro. Mutations in the Cardiac Troponin I gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.