Thermo Fisher Scientific Phospho-NFkB p50 (Ser337) Recombinant Superclonal Antibody (2HCLC)

Applications

Product Specifications

Product Specific Information

Recombinant rabbit Superclonal™ antibodies are unique offerings from Thermo Fisher Scientific.
These antibodies consist of a mixture of different recombinant monoclonal antibodies, combining the sensitivity of polyclonal antibodies with the specificity and reproducibility of monoclonal antibodies.
They recognize multiple epitope sites on the target, providing higher detection sensitivity for low-abundance targets.
The recombinant nature ensures consistent lot-to-lot performance, eliminating biological variability typical of polyclonal antibody production.
Formerly known as “Recombinant polyclonal antibody”, now rebranded as “Recombinant Superclonal™ antibody”; the product and performance remain unchanged.

Target Information

NFkB is a nuclear transcription factor activated by various stimuli such as cytokines, UV radiation, stress, and microbial products.
It regulates cellular processes including growth, differentiation, proliferation, apoptosis, and inflammation.
NFKB1 (p50) is a 50 kDa subunit of NFkB, synthesized as a p105 precursor containing the RHD region with nuclear localization, DNA-binding, and dimerization domains.
It forms homodimers or heterodimers with p65 to create the functional NFkB complex.
Phosphorylation at Ser-337 enhances DNA binding efficiency.
NFkB plays roles in diseases such as AIDS, cancer metastasis, and rheumatoid arthritis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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