Thermo Fisher Scientific FGFR1 Monoclonal Antibody (OTI6F8), TrueMAB

Applications

Western Blot (WB)

• Tested Dilution: 1:2,000

Product Specifications

Product Specific Information

For reconstitution, add 100 µL of distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

FGFR1 (also known as FLT2) is a member of the Fibroblast Growth Factor Receptor family (FGFR1–4), a group of membrane-spanning tyrosine kinases that act as high-affinity receptors for 17 growth factors (FGF1–17).
These receptors are involved in mesoderm induction, cell growth and migration, organ formation, and bone development.
FGFR1 undergoes alternative splicing, producing multiple variants expressed differently during embryonic and adult stages.
Mutations or aberrations in FGFR1 are associated with diseases such as Pfeiffer syndrome, idiopathic hypogonadotropic hypogonadism, Kallmann syndrome type 2, osteoglophonic dysplasia, and various craniofacial syndromes.
Chromosomal rearrangements involving FGFR1 are linked to stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.