Thermo Fisher Scientific FGFR1 Monoclonal Antibody (OTI3C4), TrueMAB

Applications and Tested Dilution

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

FGFR1 (also known as FLT2) belongs to the Fibroblast Growth Factor Receptor (FGFR) family, comprising four membrane-spanning tyrosine kinases (FGFR1–4) that act as high-affinity receptors for 17 fibroblast growth factors (FGF1–17).
The FGFR family is crucial in various biological processes such as mesoderm induction, cell growth, migration, organogenesis, and bone development.
FGFR1 undergoes alternative splicing, producing multiple isoforms expressed differently during embryonic and adult stages.
Mutations or aberrations in FGFR1 are linked to diseases including Pfeiffer syndrome, idiopathic hypogonadotropic hypogonadism (IHH), Kallmann syndrome type 2 (KAL2), osteoglophonic dysplasia (OGD), non-syndromic trigonocephaly, Jackson-Weiss syndrome, and Antley-Bixler syndrome.
Chromosomal abnormalities involving FGFR1 are associated with stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.