Thermo Fisher Scientific FGFR1 Monoclonal Antibody (OTI1A3), TrueMAB

Applications

Western Blot (WB)

• Tested Dilution: 1:2,000

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step (recommended: Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

FGFR1 (also known as FLT2) is a member of the Fibroblast Growth Factor Receptor family (FGFR1–4), which are membrane-spanning tyrosine kinases acting as high-affinity receptors for 17 growth factors (FGF1–17).
These receptors regulate key biological processes such as mesoderm induction, cell growth, migration, organ formation, and bone development.
FGFR1 undergoes alternative splicing, producing multiple isoforms with distinct expression patterns during development and in adult tissues.
Mutations or aberrations in FGFR1 are associated with disorders including Pfeiffer syndrome, idiopathic hypogonadotropic hypogonadism, Kallmann syndrome type 2, osteoglophonic dysplasia, non-syndromic trigonocephaly, Jackson-Weiss syndrome, and Antley-Bixler syndrome.
Chromosomal rearrangements involving FGFR1 have been linked to stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.