Thermo Fisher Scientific IRF7 Polyclonal Antibody
IRF7 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. WB, IHC, ICC/IF에 사용 가능하며 인간, 마우스, 랫트에 반응. 항원 친화 크로마토그래피로 정제된 액상 항체로, PBS에 0.02% sodium azide 함유.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 0.5–2 µg/mL | View 1 publication |
| Immunohistochemistry (IHC) | 5 µg/mL | - |
| Immunocytochemistry (ICC/IF) | 20 µg/mL | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A peptide corresponding to 14 amino acids near the carboxy terminus of human IRF7 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long-term storage, store at -20°C. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11153510 |
Product Specific Information
- Suggested positive control: 293 cell lysate
- PA5-20280 can be used with blocking peptide PEP-0414
Target Information
Interferons (IFNs) are involved in numerous immune interactions during viral infections and play a key role in both the induction and regulation of innate and adaptive antiviral mechanisms.
During infection, host-virus interactions activate downstream molecules such as transcription factors including IFN regulatory factor-3 (IRF3), which stimulate transcription of IFN-α/β genes.
IRF7 is involved in the transcriptional activation of virus-inducible cellular genes, including interferon beta chain genes, and plays a major role in the innate immune pathway. It interacts with Toll-like receptor (TLR) adaptor proteins MyD88 and Tirp/TRAM, functioning as an intermediate in TLR4 and TLR9 signaling.
There are at least four differentially spliced isoforms of IRF7, although their functions are not clearly established.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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