Thermo Fisher Scientific CD254 (RANK Ligand) Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

• Suggested positive control: Rat liver tissue lysate
• PA5-20291 can be used with blocking peptide PEP-0421

Target Information

This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation.
It acts as a dendritic cell survival factor and regulates T cell-dependent immune responses.
T cell activation induces expression of this gene, increasing osteoclastogenesis and bone loss.
This protein activates antiapoptotic kinase AKT/PKB via a signaling complex involving SRC kinase and TRAF6, indicating its role in apoptosis regulation.
Targeted disruption in mice results in severe osteopetrosis and absence of osteoclasts, defective T/B cell differentiation, and failure to form mammary structures during pregnancy.
Two alternatively spliced transcript variants have been identified.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.