Thermo Fisher Scientific CD254 (RANK Ligand) Polyclonal Antibody
RANK Ligand 단백질을 인식하는 Rabbit Polyclonal 항체로, Human, Mouse, Rat에 반응합니다. Western blot 및 IHC에 사용 가능하며, 항원 친화 크로마토그래피로 정제되었습니다. 세포사멸 조절 및 골흡수 연구에 적합합니다.
- 카탈로그번호
- PA520291
- 판매단위
- pk
카탈로그
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 0.25–0.5 µg/mL | - |
| Immunohistochemistry (IHC) | – | 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 5 µg/mL | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A 14 amino acid peptide from near the center of human sRANK-L |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long term storage, store at -20°C. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11156031 |
Product Specific Information
- Suggested positive control: Rat liver tissue lysate
- PA5-20291 can be used with blocking peptide PEP-0421
Target Information
This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation.
It acts as a dendritic cell survival factor and regulates T cell-dependent immune responses.
T cell activation induces expression of this gene, increasing osteoclastogenesis and bone loss.
This protein activates antiapoptotic kinase AKT/PKB via a signaling complex involving SRC kinase and TRAF6, indicating its role in apoptosis regulation.
Targeted disruption in mice results in severe osteopetrosis and absence of osteoclasts, defective T/B cell differentiation, and failure to form mammary structures during pregnancy.
Two alternatively spliced transcript variants have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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