Thermo Fisher Scientific FAIM3 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1–2 µg/mL
• Suggested positive control: Human lung tissue lysate
• Blocking peptide: PEP-0403

Product Specifications

Product Specific Information

Despite its predicted molecular weight, Toso often migrates at 60 kDa in SDS-PAGE. A suggested positive control is human lung tissue lysate.
PA5-20285 can be used with blocking peptide PEP-0403.

Target Information

Apoptosis is an important process by which normal tissue homeostasis and function are maintained. One of the major signals regulating this process is mediated by activation of the Fas receptor by its ligand. This leads to formation of a Fas-associated death domain (FADD)-containing death-inducing signaling complex and activation of caspase-8, which in turn activates downstream effector caspases such as caspase-3 and -7.

Recent studies show that overexpression of Toso, a novel regulator of Fas-induced apoptosis in lymphoid cells, in Jurkat cells and transgenic mice renders these cells resistant to Fas-induced apoptosis but not to TRAIL-induced apoptosis. Furthermore, Toso associates with FADD, suggesting that Toso functions by disrupting formation of the death-inducing signaling complex.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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