Thermo Fisher Scientific PKR Polyclonal Antibody
PKR 단백질을 인식하는 Rabbit Polyclonal 항체로, Human, Mouse, Rat에 반응함. Western blot 및 IHC(P)에서 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, PBS와 sodium azide를 포함한 액상 형태. 냉장 및 장기 보관 가능.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.5–1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 2.5–5 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A peptide near the carboxy terminus of human PKR (UniProt ID: P19525-1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long-term storage, store at -20°C. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11154994 |
Product Specific Information
- Suggested positive control: A431 cell lysate
- PA5-20283 can be used with blocking peptide PEP-0417
- Immunogen located within the last 50 amino acids of PKR
- Predicted molecular weight: ~62 kDa
- Observed band in Western blot: 68 kDa
Target Information
EIF2AK2 (PKR) is one of four kinases that specifically phosphorylate Ser51 of translation initiation factor eIF2-alpha in response to environmental stresses. PKR plays a key role in antiviral defense by activation through double-stranded RNA produced during viral infection. It mediates IFN-induced innate antiviral response, virus-induced apoptosis, and regulation of cell growth and differentiation. PKR induces apoptosis via Fas expression and FADD/Caspase-8 signaling. It can activate both survival and death pathways depending on kinase activity. PKR is involved in multiple signaling pathways, including NF-kappaB, p53, p38, and PDGF. It has implications in tumor suppression and neurodegenerative diseases such as Alzheimer’s, Huntington’s, and ALS. Viruses can inhibit PKR activity, e.g., influenza virus NS1 protein.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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