Thermo Fisher Scientific FOLR2 Monoclonal Antibody (EM-35)
FOLR2 단백질을 인식하는 EM-35 클론의 마우스 모노클로날 항체로, 인간 시료에 반응합니다. Western blot, ICC/IF, Flow cytometry, IP 등 다양한 응용에 적합합니다. 비결합형 액상 형태로 제공되며, Protein A로 정제되어 4°C에서 보관합니다.
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Thermo Fisher Scientific FOLR2 Monoclonal Antibody (EM-35)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | Assay-dependent |
| Immunocytochemistry (ICC/IF) | Assay-dependent |
| Flow Cytometry (Flow) | 1–4 µg/mL |
| Immunoprecipitation (IP) | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | EM-35 |
| Immunogen | BW5147α,β- cells expressing FOLR2 (UniProt ID: P14207-1, antigen range 1–255) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 15 mM sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2745511 |
Additional Formats
Product Specific Information
This antibody recognizes an extracellular epitope on FOLR2, a 30–40 kDa cell surface protein serving as a receptor for folic acid.
Western blot should be performed under non-reducing conditions.
Target Information
FOLR2 is a member of the folate receptor (FOLR) family, which forms a gene cluster on chromosome 11. These receptors exhibit high affinity for folic acid and reduced folate derivatives, mediating cellular uptake of 5-methyltetrahydrofolate.
FOLR2 shares 68% and 79% sequence homology with FOLR1 and FOLR3, respectively. Initially thought to be placenta-specific, it is also expressed in other tissues and may contribute to methotrexate transport in synovial macrophages of rheumatoid arthritis patients.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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