Thermo Fisher Scientific Arginase 1 Polyclonal Antibody

Applications

• Western Blot (WB): 1:500–1:1,000

Product Specifications

Product Specific Information

• Purity is >95% by SDS-PAGE.

Target Information

Arginase-1 (Arg1) is a 35 kDa enzyme that converts L-arginine to urea and L-ornithine, the final step in the urea cycle. Polyamines produced are essential for cell proliferation and detoxification. By degrading arginine, Arginase 1 reduces substrate availability for NO synthase, thereby down-regulating nitric oxide production.
In humans and mice, Arginase 1 is expressed in the liver, neutrophils, myeloid-derived suppressor cells (MDSC), and neural stem cells. In humans, expression occurs in blood neutrophils but not CCR3+ granulocytes. In mice, it marks alternatively activated macrophages (M2a). It may also be expressed in tumor-infiltrating myeloid cells and is commonly found in hepatocellular carcinoma.
Defects in Arginase 1 cause argininemia, an autosomal recessive disorder characterized by hyperammonemia.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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