Thermo Fisher Scientific Arginase 1 Polyclonal Antibody
Thermo Fisher Scientific의 Arginase 1 Polyclonal Antibody는 인간 Arginase-1 단백질(aa 105-150)에 특이적인 토끼 IgG 항체입니다. Western blot에 적합하며, 고순도(>95%)로 정제된 액상 형태입니다. 연구용으로 세포 대사 및 NO 합성 조절 연구에 활용됩니다.
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Applications
- Western Blot (WB): 1:500–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 105–150 of Human ARG1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term; for long term, store at -20°C, avoiding freeze/thaw cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2803448 |
Product Specific Information
- Purity is >95% by SDS-PAGE.
Target Information
Arginase-1 (Arg1) is a 35 kDa enzyme that converts L-arginine to urea and L-ornithine, the final step in the urea cycle. Polyamines produced are essential for cell proliferation and detoxification. By degrading arginine, Arginase 1 reduces substrate availability for NO synthase, thereby down-regulating nitric oxide production.
In humans and mice, Arginase 1 is expressed in the liver, neutrophils, myeloid-derived suppressor cells (MDSC), and neural stem cells. In humans, expression occurs in blood neutrophils but not CCR3+ granulocytes. In mice, it marks alternatively activated macrophages (M2a). It may also be expressed in tumor-infiltrating myeloid cells and is commonly found in hepatocellular carcinoma.
Defects in Arginase 1 cause argininemia, an autosomal recessive disorder characterized by hyperammonemia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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