Thermo Fisher Scientific TNFAIP3 Polyclonal Antibody
TNFAIP3 단백질을 인식하는 Thermo Fisher Scientific의 폴리클로날 항체로, 인간·마우스·랫트 반응성이 있습니다. Western blot 및 면역세포화학(ICC/IF)에 적합하며, 고순도(>95%) 항원 친화 크로마토그래피 정제 제품입니다. 장기 보관은 -20°C에서 권장됩니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 365–410 of Human TNFAIP3 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS (pH 7.2) with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term; for long term, store at -20°C (avoid freeze/thaw cycles) |
| Shipping Conditions | Wet ice |
| RRID | AB_2803444 |
Product Specific Information
- Purity is >95% by SDS-PAGE.
Target Information
TNFAIP3, also known as A20, is located in chromosome band 6q23, a region frequently deleted in B-cell lymphomas. It functions as a tumor suppressor gene in Hodgkin lymphoma and several subtypes of non-Hodgkin lymphomas.
TNFAIP3 encodes a zinc-finger protein rapidly induced by TNF-α, inhibiting NF-κB-dependent gene expression and protecting cells from TNF-α cytotoxicity.
Overexpression of TNFAIP3 inhibits TLR2- and TLR4-mediated interleukin-8 synthesis in airway epithelial cells, acting as a negative regulator of TLR-mediated inflammatory responses.
At least two isoforms of TNFAIP3 are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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