Thermo Fisher Scientific SPHK1 Recombinant Rabbit Monoclonal Antibody (JA31-14)
SPHK1 단백질을 인식하는 재조합 토끼 단일클론 항체로, 높은 특이성과 민감도를 제공. Western blot, IHC, Flow cytometry 등 다양한 응용에 적합. 로트 간 일관성과 동물 유래 성분이 없는 제형으로 연구 재현성 향상. 단기 4°C, 장기 -20°C 보관.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Flow Cytometry (Flow) | 1:50 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | JA31-14 |
| Immunogen | Synthetic peptide within Human SPHK1 aa 25–74 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 40% Glycerol, 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2809986 |
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems developed by cloning specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select the best candidates for production.
Advantages include:
- Better specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulations
- Broader immunoreactivity due to larger rabbit immune repertoire
Target Information
SPHK1, along with SPHK2, catalyzes the phosphorylation of sphingosine to produce sphingosine-1-phosphate (S1P), a key signaling molecule.
S1P signals through G-protein coupled receptors and regulates diverse cellular processes such as:
- Cell differentiation
- Calcium mobilization from intracellular stores
- Apoptosis
Inhibitors of SPHKs are considered potential therapeutics for cancer treatment.
S1P also interacts with EDG family G protein-coupled receptors (S1P Receptors).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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