Thermo Fisher Scientific IP3 Receptor 1 Recombinant Rabbit Monoclonal Antibody (JA11-35)
Recombinant rabbit monoclonal antibody recognizing IP3 Receptor 1. Validated for WB and IHC (Paraffin). Offers high specificity, sensitivity, and lot-to-lot consistency. Suitable for human, mouse, and rat samples. For research use only.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | JA11-35 |
| Immunogen | Recombinant protein within Human IP3 Receptor aa 2190–2280 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 40% Glycerol, 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2809987 |
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The antibody DNA sequences from immunoreactive rabbits are cloned and screened to select optimal clones for production.
Advantages include:
- Enhanced specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulation
- Broad immunoreactivity due to the rabbit immune repertoire
Target Information
The IP3 Receptor 1 is an intracellular calcium channel mediating calcium release from the endoplasmic reticulum upon stimulation by inositol 1,4,5-trisphosphate.
It regulates epithelial secretion of electrolytes and fluids via interaction with AHCYL1 and plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER activates CaM kinase II, leading to downstream apoptotic pathways.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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