Thermo Fisher Scientific TrxR1 Recombinant Rabbit Monoclonal Antibody (JA11-32)
TrxR1 단백질을 인식하는 재조합 토끼 단클론 항체로, Western blot, IHC, ICC/IF, Flow cytometry에 적합. 높은 특이성과 일관된 로트 간 품질을 제공하며, 동물 유래 성분이 없는 포뮬레이션으로 연구 재현성 향상.
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Thermo Fisher Scientific TrxR1 Recombinant Rabbit Monoclonal Antibody (JA11-32)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| Flow Cytometry (Flow) | 1:50–1:100 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host/Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | JA11-32 |
| Immunogen | Recombinant protein with Human TXNRD1 aa 1–649 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 40% Glycerol, 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2809989 |
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. These systems clone specific antibody DNA sequences from immunoreactive rabbits, followed by screening individual clones to select optimal candidates for production.
Advantages include:
- Superior specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulations
- Broader immunoreactivity due to the larger rabbit immune repertoire
Target Information
This gene encodes a member of the pyridine nucleotide oxidoreductase family. The protein reduces thioredoxins and other substrates, contributing to selenium metabolism and protection against oxidative stress.
The enzyme functions as a homodimer using FAD as a cofactor. Each subunit contains a selenocysteine (Sec) residue essential for catalytic activity. The Sec is encoded by the UGA codon, typically a stop signal, but recognized as Sec through a SECIS element in the 3′ UTR.
Alternative splicing yields multiple transcript variants encoding similar or distinct isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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