Thermo Fisher Scientific SEMA3F Polyclonal Antibody

Applications

• Western Blot (WB): Tested dilution 1:100
• Publications: [References not provided]

Product Specifications

Product Specific Information

The antibody detects a 95 kDa* protein corresponding to the apparent molecular mass of Sema-3F on SDS-PAGE immunoblots of adult mouse brain and liver.

Target Information

The semaphorins are a family of proteins involved in signaling. All family members have a secretion signal, a 500-amino acid sema domain, and 16 conserved cysteine residues (Kolodkin et al., 1993 [PubMed 8269517]).
Sequence comparisons have grouped the secreted semaphorins into three general classes, all of which also have an immunoglobulin domain.
The semaphorin III family—including human semaphorin III (SEMA3A; MIM 603961), chicken collapsin, and mouse semaphorins A, D, and E—all have a basic domain at the C terminus.
Chicken collapsin contributes to pathfinding by axons during development by inhibiting growth cone extension (Luo et al., 1993 [PubMed 8402908]) through interaction with a collapsin response mediator protein (CRMP62) (Goshima et al., 1995 [PubMed 7637782]), a homolog of the UNC33 gene product (MIM 601168).
SEMA3F is a secreted member of the semaphorin III family.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.