Thermo Fisher Scientific Bcl-rambo Monoclonal Antibody (Rocky-2)
인간 Bcl-rambo 단백질을 검출하는 마우스 단클론 항체로 Western blot, ICC/IF, IP에 적합합니다. 비결합형 액상 형태이며 Protein G로 정제되었습니다. 세포사멸 연구 및 Bcl-2 패밀리 단백질 분석에 유용합니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:300 |
| Immunoprecipitation (IP) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | Rocky-2 |
| Immunogen | Recombinant fragment corresponding to the C-terminal residues 224–459 of human Bcl-rambo, fused at the N-terminus to a tag |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_779369 |
Product Specific Information
MA1-25847 detects Bcl-rambo from human samples.
Target Information
Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in various diseases such as cancer. Members of the Bcl-2 family are critical regulators of apoptosis and are characterized by conserved Bcl-2 homology (BH) domains.
A novel, widely expressed member termed Bcl-rambo was recently identified. This mitochondrial protein induces apoptosis when overexpressed, which can be blocked by co-expression of inhibitor of apoptosis proteins (IAPs) such as XIAP, cIAP1, and cIAP2.
Bcl-rambo shows overall homology to anti-apoptotic members containing BH motifs, but unlike Bcl-2, its C-terminal membrane anchor is preceded by a unique 250 amino acid insertion. This region alone can induce apoptosis more efficiently than the BH domains, suggesting Bcl-rambo may play a role in other pro-apoptotic pathways.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지: MA1-25847_Bcl-rambo_Q9BXK5-1_House_mouse.svg, MA1-25847_Bcl-rambo_Q9BXK5-1_House_mouse_PDP.jpeg)
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