Thermo Fisher Scientific TNFRSF14 Monoclonal Antibody (Laury-1)

Applications

Tested Dilution

Publications

Flow Cytometry (Flow)

1:1,000

-

Immunoprecipitation (IP)

1:200

-

Product Specifications

Host/Isotype

Rat / IgG2a

Class

Monoclonal

Type

Antibody

Clone

Laury-1

Immunogen

Fusion protein corresponding to the extracellular domain (residues 39-200) of human TNFRSF14, fused to the Fc portion of human IgG1. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:TNFRSF14 (HVEM),uniProtId:Q92956-1,ncbiNodeId:9606,antigenRange:39-200,antigenLength:283,antigenImageFileName:MA1-25844_TNFRSF14_HVEM_Q92956-1_Rat.svg,antigenImageFileNamePDP:MA1-25844_TNFRSF14_HVEM_Q92956-1_Rat_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Storage conditions

4° C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_794528

Product Specific Information

MA1-25844 detects TNFRSF14 from human samples.

Target Information

TNFRSF14 is a member of the TNF-receptor superfamily. TNFRSF14 was identified as a cellular mediator of herpes simplex virus (HSV) entry. Binding of HSV viral envelope glycoprotein D (gD) to TNFRSF14 has been shown to be part of the viral entry mechanism. The cytoplasmic region of TNFRSF14 was found to bind to several TRAF family members, which may mediate the signal transduction pathways that activate the immune response. Activation of the signal transduction pathway involving TNFRSF14 in T cells stimulates T cell proliferation and cytokine production, leading to inflammation and enhanced CTL-mediated tumor immunity, suggesting that these proteins may be useful as potential targets for controlling cellular immune responses. Multiple alternatively spliced transcript variants have been described, but the full-length nature of some of these TNFRSF14 variants have not been determined.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.