Thermo Fisher Scientific Phospho-SRC (Tyr419) Recombinant Rabbit Monoclonal Antibody (ST0800)
SRC 단백질의 Tyr419 인산화 상태를 검출하는 고특이성 재조합 토끼 단일클론 항체. Western blot, ICC/IF, Flow cytometry에 적합. 높은 로트 간 일관성과 민감도 제공. 연구용으로만 사용 가능.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:50 |
| Flow Cytometry (Flow) | 1:50–1:100 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host/Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | ST0800 |
| Immunogen | Synthetic phospho-peptide corresponding to residues surrounding Tyr419 of human Src (aa 401–450) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 40% Glycerol, 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2809433 |
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The antibody DNA sequences from immunoreactive rabbits are cloned and screened to select optimal candidates for production.
Advantages of recombinant rabbit monoclonal antibodies include:
- Enhanced specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulations
- Broader immunoreactivity due to the larger rabbit immune repertoire
Target Information
SRC is a cytoplasmic tyrosine kinase and proto-oncogene regulating embryonic development and cell growth. It associates with various cell surface receptors for signal transduction and is involved in cytoskeletal organization, cell cycle regulation, and apoptosis.
In humans, SRC is encoded on chromosome 20. Its activity is controlled by phosphorylation at Tyr416 and Tyr527, which have opposing effects—phosphorylation at Tyr416 activates SRC, while Tyr527 phosphorylation inhibits it.
Mutations in SRC may contribute to malignant progression in colon cancer. Two transcript variants encoding the same SRC protein have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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