Thermo Fisher Scientific CYP17A1 Recombinant Rabbit Monoclonal Antibody (ARC1257)
CYP17A1 단백질을 표적하는 재조합 토끼 단클론 항체로, Western blot, ICC/IF, ELISA에 적합합니다. 인간 및 마우스 반응성을 가지며 HEK293 세포에서 발현되었습니다. 고순도 친화 크로마토그래피 정제 및 안정한 PBS/glycerol 완충액 형태로 제공됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:6,000 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host/Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | ARC1257 |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 101–220 of human CYP17A1 (P05093) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol, 0.05% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20 °C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2849532 |
Product Specific Information
Immunogen sequence:
TLDIASNNRK GIAFADSGAH WQLHRRLAMA TFALFKDGDQ KLEKIICQEI STLCDMLATH NGQSIDISFP VFVAVTNVIS LICFNTSYKN GDPELNVIQN YNEGIIDNLS KDSLVDLVPW
Target Information
The CYP17A1 gene encodes a member of the cytochrome P450 superfamily of enzymes. These monooxygenases catalyze reactions involved in drug metabolism and synthesis of cholesterol, steroids, and other lipids. This protein localizes to the endoplasmic reticulum and has both 17α-hydroxylase and 17,20-lyase activities. It is a key enzyme in the steroidogenic pathway producing progestins, mineralocorticoids, glucocorticoids, androgens, and estrogens.
Mutations in this gene are associated with isolated steroid-17α-hydroxylase deficiency, 17α-hydroxylase/17,20-lyase deficiency, pseudohermaphroditism, and adrenal hyperplasia.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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