Thermo Fisher Scientific Phospho-HDAC5 (Ser259) Polyclonal Antibody
HDAC5의 Ser259 인산화 형태를 특이적으로 검출하는 폴리클로날 항체로, Western blot 및 Immunocytochemistry에 적합. 사람과 생쥐 시료에 반응하며, 고순도 정제 및 안정적 PBS/glycerol 저장 버퍼 제공. 연구용으로만 사용 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human HDAC5 (Accession Q9UQL6), corresponding to amino acid residues around phosphorylated Ser259 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2816513 |
Product Specific Information
This antibody detects endogenous levels of HDAC5 only when phosphorylated at Serine 259.
Target Information
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the class II histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. It coimmunoprecipitates only with HDAC3 family member and might form multicomplex proteins. It also interacts with myocyte enhancer factor-2 (MEF2) proteins, resulting in repression of MEF2-dependent genes. This gene is thought to be associated with colon cancer. Two transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일명: PA5-105040_HDAC5_Q9UQL6-1_Rabbit.svg, PA5-105040_HDAC5_Q9UQL6-1_Rabbit_PDP.jpeg)
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