Thermo Fisher Scientific COL11A2 Monoclonal Antibody (GT473)
COL11A2 단백질을 인식하는 mouse monoclonal antibody(GT473)로, WB, IHC, ICC/IF에 적합합니다. Human, Mouse, Rat 반응성이 있으며, 1 mg/mL 농도의 액상형 제품입니다. 단기 4°C, 장기 -20°C 보관을 권장합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:3,000 | - |
| Immunohistochemistry (IHC) | - | 1 publication |
| Immunocytochemistry (ICC/IF) | 1:100–1:1,000 | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | GT473 |
| Immunogen | Recombinant protein encompassing a sequence within the N-terminus region of human COL11A2 (exact sequence proprietary) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2735152 |
Product Specific Information
- Positive Control: Human COL11A2-transfected 293T cells (N-terminal fragment of COL11A2 isoform 1)
- Predicted Reactivity: Mouse (85%), Rat (85%), Bovine (93%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
The COL11A2 gene encodes one of the two alpha chains of type XI collagen, a minor fibrillar collagen located on chromosome 6 near the retinoid X receptor beta gene. Type XI collagen is a heterotrimer, with the third alpha chain derived from a post-translationally modified alpha 1 type II chain. Proteolytic processing of this chain produces PARP, a proline/arginine-rich protein forming the amino terminal domain.
Mutations in COL11A2 are associated with:
- Type III Stickler syndrome
- Otospondylomegaepiphyseal dysplasia (OSMED syndrome)
- Weissenbacher-Zweymuller syndrome
- Autosomal dominant non-syndromic sensorineural deafness type 13 (DFNA13)
- Autosomal recessive non-syndromic sensorineural deafness type 53 (DFNB53)
Alternative splicing results in multiple transcript variants. A related pseudogene is located nearby on chromosome 6.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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