Thermo Fisher Scientific ENO1 Monoclonal Antibody (GT2217)
Thermo Fisher ENO1 Monoclonal Antibody (GT2217)은 인간 ENO1 단백질을 인식하는 마우스 IgG2b 항체로, Western blot에 최적화되어 있습니다. 고순도 Protein G 정제, 액상 형태이며 1 mg/mL 농도입니다. 암, 저산소성 뇌손상, 자가면역 질환 연구에 활용됩니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:5,000–1:20,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | GT2217 |
| Immunogen | Recombinant protein encompassing a sequence within the center region of human ENO1 (exact sequence proprietary) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2735175 |
Product Specific Information
- Positive Control: 293T, A549, H1299, HCT116
- Predicted Reactivity: Mouse (94%), Rat (93%), Xenopus laevis (90%), Chicken (93%), Rhesus Monkey (100%), Chimpanzee (100%), Bovine (93%), Guinea pig (95%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Enolase (2-phosphoglycerate hydrolyase or phosphopyruvate hydrates) is a glycolytic enzyme that catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate. It consists of three subunits—alpha, beta, and gamma.
Non-neuronal enolase (ENO1) is an isoform composed of two alpha subunits. The ENO1 gene also encodes tau-crystallin, a monomeric structural lens protein.
ENO1 is multifunctional, involved in glycolysis, growth control, hypoxia tolerance, and allergic responses. It may act as a receptor and activator of plasminogen on cell surfaces, contributing to fibrinolytic processes. Additionally, ENO1 stimulates immunoglobulin production and serves as a diagnostic marker for various tumors, hypoxic brain injury, and endometriosis.
Antibodies against ENO1 are found in cancer-associated retinopathy syndrome (CAR) and Hashimoto encephalopathy (HE), both autoimmune conditions linked to systemic malignancies or thyroid disorders.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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