Thermo Fisher Scientific CD254 (RANK Ligand) Monoclonal Antibody (12A380)
CD254 (RANK Ligand) 단클론 항체(12A380)는 인간 및 생쥐 시료에서 sRANKL 검출에 적합합니다. Western blot, IHC, Flow Cytometry 등 다양한 응용에 사용 가능하며, Protein G 정제된 액상 형태로 제공됩니다. 뼈 대사 및 면역 반응 연구에 유용합니다.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 4–6 µg/mL | - |
| Immunohistochemistry (IHC) | - | 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:250 | 1 publication |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:10–1:500 | - |
| Flow Cytometry (Flow) | 1:10–1:1,000 | - |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Mouse |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 12A380 |
| Immunogen | Fusion protein containing amino acid residues 1–317 of human TRANCE/RANKL |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_561794 |
Product Specific Information
MA1-20347 detects sRANKL in Human and Mouse samples.
Target Information
This gene encodes a member of the tumor necrosis factor (TNF) cytokine family, a ligand for osteoprotegerin, and a key factor for osteoclast differentiation and activation. It functions as a dendritic cell survival factor and regulates T cell-dependent immune responses. T cell activation induces expression of this gene, leading to increased osteoclastogenesis and bone loss. It activates antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and TRAF6, suggesting a role in cell apoptosis regulation. Gene disruption in mice results in severe osteopetrosis, absence of osteoclasts, defects in early T and B lymphocyte differentiation, and failure to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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