Thermo Fisher Scientific HDAC1 Monoclonal Antibody (HDAC1-21)

Applications

Tested Dilution

Publications

Western Blot (WB)

2-4 µg/mL

View 1 publication 1 publication

ELISA (ELISA)

Assay-dependent

-

Immunoprecipitation (IP)

Assay-dependent

-

ChIP assay (ChIP)

2.5 µg/10^6 cells

-

Product Specifications

Published species

Human

Host/Isotype

Mouse / IgG3

Class

Monoclonal

Type

Antibody

Clone

HDAC1-21

Immunogen

Synthetic peptide corresponding to residues K(466) E E K P E A K G V K E E V K L A(482) of human HDAC1. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:HDAC1,uniProtId:Q13547-1,ncbiNodeId:9606,antigenRange:466-482,antigenLength:482,antigenImageFileName:MA1-20354_HDAC1_Q13547-1_House_mouse.svg,antigenImageFileNamePDP:MA1-20354_HDAC1_Q13547-1_House_mouse_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

2.4 mg/mL

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_559382

Product Specific Information

Expected to cross react with rat due to sequence homology.

MA1-20354 detects a band ~65 kDa by Western blot. Possible positive controls for this product are HeLa cell whole cell lysate.

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. HDAC1 belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, HDAC1 deacetylates p53 and modulates its effect on cell growth and apoptosis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.