Thermo Fisher Scientific HLA-DR Monoclonal Antibody (LN3), APC, eBioscience
인간 HLA-DR 항원을 인식하는 LN3 클론 단일클론 항체로, APC 형광 표지되어 있습니다. Flow cytometry에 최적화되어 있으며, 5 µL/test로 사용 가능합니다. 항원제시세포 표면의 MHC Class II 검출에 적합하고, 고품질 정제 및 안정적 보관 조건을 제공합니다.
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Thermo Fisher Scientific HLA-DR Monoclonal Antibody (LN3), APC, eBioscience
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | - | View 1 publication |
| Immunohistochemistry (Frozen) (IHC (F)) | - | View 1 publication |
| Flow Cytometry (Flow) | 5 µL (0.0075 µg)/test | View 36 publications |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Recommended Isotype Control | Mouse IgG2b kappa Isotype Control (eBMG2b), APC, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | LN3 |
| Conjugate | APC |
| Excitation / Emission Max | 651 / 660 nm |
| Form | Liquid |
| Concentration | 5 µL/test |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 0.2% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10671395 |
Available Formats
- Unconjugated
- Alexa Fluor 660
- Alexa Fluor 700
- Alexa Fluor Plus 488
- Alexa Fluor Plus 647
- APC-eFluor 780
- Biotin
- Brilliant UV 395 / 496 / 563 / 615 / 661 / 737 / 805
- Brilliant Violet 421 / 480 / 605 / 711 / 786
- eFluor 450 / 506
- FITC
- NovaFluor Blue 510 / 530 / 555 / 610-30S / 660-40S / 725 / 800
- NovaFluor UV 765 / Violet 690 / Violet 800 / Yellow 810
- PE / PE-Cyanine5 / PE-Cyanine7 / PE-eFluor 610
- PerCP-Cyanine5.5
- Super Bright 436 / 600 / 645 / 702 / 780
- Request custom conjugation
Product Specific Information
Description:
The LN3 monoclonal antibody recognizes the human MHC class II molecule HLA-DR. HLA-DR is expressed on antigen-presenting cells (APC) such as B cells, monocytes, macrophages, dendritic cells, and activated T cells. It plays a key role in peptide presentation to CD4⁺ T lymphocytes.
Applications Reported:
The LN3 antibody is validated for flow cytometric analysis.
Applications Tested:
Pre-titrated and tested by flow cytometry on human peripheral blood cells. Recommended usage: 5 µL (0.0075 µg) per test (100 µL final volume, 10⁵–10⁸ cells/test).
Excitation / Emission:
633–647 nm / 660 nm (Red Laser)
Filtration:
0.2 µm post-manufacturing filtered
Target Information
HLA-DR is a transmembrane glycoprotein composed of a 36 kDa alpha chain (DRA) and 27 kDa beta chain (DRB). The alpha chain gene contains five exons encoding leader peptide, extracellular domains, transmembrane domain, and cytoplasmic tail.
DRA is non-polymorphic, while DRB carries polymorphisms defining peptide binding specificity. HLA-DR is expressed mainly on antigen-presenting cells (B cells, monocytes, macrophages, thymic epithelial cells, activated T cells).
MHC class II molecules (DR, DQ, DP) are essential for peptide presentation to T-helper cells and initiation of immune responses.
HLA/MHC antibodies are pivotal in immunopeptidomics for identifying neoantigens via LC-MS/MS.
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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