Thermo Fisher Scientific Phospho-ZAP70/Syk (Tyr493, Tyr526) Recombinant Rabbit Monoclonal Antibody (Zap70Y493-H11), APC
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Applications
Tested Dilution
Publications
Flow Cytometry (Flow)
5 µL/1x10^6 cells
Product Specifications
Host/Isotype
Rabbit / IgG, kappa
Class
Recombinant Monoclonal
Type
Antibody
Clone
Zap70Y493-H11
Immunogen
A synthetic phospho-peptide corresponding to residues surrounding Tyr493 of human phospho Zap70. if (typeof window.$mangular === undefined
|| !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{
targetFamily:
Zap-70,
uniProtId:
P43403-1,
ncbiNodeId:
9606,
antigenRange:
493,
antigenLength:
619,
antigenImageFileName:
MA5-36918_Zap-70_P43403-1_Rabbit.svg,
antigenImageFileNamePDP:
MA5-36918_Zap-70_P43403-1_Rabbit_PDP.jpeg,
sortOrder:
1}\]
; $mangular.isB2BCMGT = false
; $mangular.isEpitopesModalImageMultiSizeEnabled = true
;
View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}
Conjugate
APC APC APC
Excitation/Emission Max
651/660 nm View spectra
Form
Liquid
Storage conditions
2-8°C
Shipping conditions
Wet ice
Target Information
ZAP-70 is a cytosolic protein tyrosine kinase that is a member of the Syk family of proteins. ZAP-70 is expressed exclusively in T-cells and natural killer cells and is required for T-cell receptor activation. Upon T cell antigen receptor (TCR) engagement, ZAP70 is phosphorylated on tyrosines 292, 315 and 319 in the interdomain B, located between the SH2 and kinase domains. Phosphorylation of both tyrosines 315 (a Vav binding site) and 319 (a Lck binding site) enhances ZAP70 function in mediating lymphocyte signaling, while tyrosine 292 terminates the transient activation of ZAP70 and attentuates lymphocyte signaling.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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