Thermo Fisher Scientific Phospho-PLCg2 (Tyr759) Recombinant Rabbit Monoclonal Antibody (PLCG2Y759-G3), APC
Phospho-PLCγ2 (Tyr759)을 인식하는 재조합 토끼 단클론 항체로, APC 형광표지되어 있습니다. Flow Cytometry에 적합하며 인간 및 마우스 시료에 반응합니다. 높은 특이성과 재현성을 제공하며, 단백질 A/G로 정제된 액상 형태입니다.
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Applications
Flow Cytometry (Flow)
- Tested Dilution: 5 µL / 1×10⁶ cells
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | PLCG2Y759-G3 |
| Immunogen | A synthetic phospho-peptide corresponding to residues surrounding Tyr759 of human phospho PLCγ2 |
| Conjugate | APC |
| Excitation / Emission Max | 651 / 660 nm |
| Form | Liquid |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.2% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2896857 |
Additional Formats
- Unconjugated (MA5-36919)
- FITC (MA5-36921)
- PE (MA5-36920)
- Custom conjugation available on request
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems by cloning specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select optimal candidates for production.
Advantages:
- Improved specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulation
- Broader immunoreactivity due to larger rabbit immune repertoire
Target Information
Phosphoinositide-specific phospholipase C (PLC) plays a key role in receptor-mediated signal transduction by generating second messengers inositol 1,4,5-triphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate.
Mammalian PLC isozymes include:
- PLCβ1, PLCβ2, PLCβ3, PLCβ4
- PLCγ1, PLCγ2
- PLCδ1, PLCδ2
- PLCε
PLCδ1 acts as a calcium signal amplifier and is activated by atypical GTP-binding proteins. It is highly expressed in brain, heart, lung, and testis, and has been associated with Alzheimer’s disease pathology. PLCδ2 expression is linked to gastric malignant transformation and may serve as a marker for neoplastic progression.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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