Thermo Fisher Scientific Phospho-WNK1 (Thr60) Polyclonal Antibody
WNK1 단백질의 Thr60 인산화 부위를 인식하는 Rabbit Polyclonal 항체로, WB, IHC, ELISA에 사용 가능. 인간, 생쥐, 랫트 반응성. 고순도 항원 친화 크로마토그래피 정제. 혈압 및 전해질 항상성 연구에 적합.
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Thermo Fisher Scientific Phospho-WNK1 (Thr60) Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (IHC) | 1:100–1:300 |
| ELISA | 1:5,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthesized peptide derived from human WNK1 around the phosphorylation site of Thr60 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 0.5% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2605422 |
Product Specific Information
This antibody is predicted to react with mouse and rat based on sequence homology.
Target Information
WNK1 serine/threonine kinase is a member of the WNK subfamily and may regulate blood pressure by controlling sodium and chloride ion transport. Mutations in WNK1 are linked to pseudohypoaldosteronism type II and hereditary sensory neuropathy type II.
WNK1 plays a crucial role in electrolyte homeostasis, cell signaling, survival, and proliferation. It acts as both activator and inhibitor of sodium- and potassium-coupled chloride cotransporters, respectively, and activates SCNN1A, SCNN1B, SCNN1D, and SGK1.
WNK1 localizes to the distal nephron, a kidney segment involved in salt, potassium, and pH homeostasis. Mutations in this gene can cause pseudohypoaldosteronism and neuropathy.
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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