Thermo Fisher Scientific Phospho-Syk (Tyr525) Polyclonal Antibody
Human 및 Mouse 등 다양한 종에서 반응하는 Phospho-Syk (Tyr525) 폴리클로날 항체. Western Blot과 Immunohistochemistry에 적합. 항원 친화 크로마토그래피로 정제된 고품질 항체로, 신호 전달 및 면역 관련 연구에 활용 가능.
- 판매단위
- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
- View 1 publication
Immunohistochemistry (IHC)
- Tested Dilution: 1:100–1:300
- View publication
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate, Rat |
| Published Species | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthesized peptide derived from human Syk around the phosphorylation site of Y525 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS (pH 7.4) with 0.5% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2608763 |
Product Specific Information
This antibody is predicted to react with mouse and rat based on sequence homology.
Target Information
Spleen tyrosine kinase (SYK), along with ZAP70, are cytoplasmic tyrosine kinases that are viewed as potential drug targets for allergic disorders and autoimmune diseases. SYK may also play a role in cancer.
Syk translocates to the plasma membrane upon B cell antigen receptor (BCR) or high-affinity IgE receptor (FcεRI) triggering, and phosphorylates downstream adaptor proteins, providing docking sites for initiation of subsequent signaling pathways such as calcium mobilization, cytoskeleton remodeling, or transcription of specific genes.
Syk binds to receptor assemblies through interactions of its SH2 domains with ITAM motifs phosphorylated by Src-family kinases, which also activate Syk by phosphorylation of its activation loop.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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