Thermo Fisher Scientific Phospho-DAXX (Ser668) Polyclonal Antibody
인산화된 DAXX(Ser668)을 인식하는 Rabbit Polyclonal 항체로, WB, IHC, ICC/IF, ELISA 등에 사용 가능. 인간 시료 반응성. 항원 친화 크로마토그래피로 정제되었으며, PBS 기반 완충액에 보관. 연구용으로만 사용.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1 µg/mL |
| Immunohistochemistry (IHC) | 1:100–1:300 |
| Immunohistochemistry (Paraffin) (IHC-P) | Assay-dependent |
| Immunocytochemistry (ICC/IF) | 5 µg/mL |
| ELISA | 1:10,000 |
Product Specifications
| Item | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthesized peptide derived from human DAXX around the phosphorylation site of Ser668 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 0.5% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2576742 |
Target Information
This gene encodes a multifunctional protein that resides in both the nucleus and cytoplasm. It interacts with various proteins, including apoptosis antigen Fas, centromere protein C, and transcription factor E26 oncogene homolog 1. In the nucleus, it acts as a potent transcription repressor that binds sumoylated transcription factors, and its repression can be relieved by sequestration into promyelocytic leukemia nuclear bodies or nucleoli. It also associates with centromeres during G2 phase. In the cytoplasm, the protein may regulate apoptosis. Its localization and function are modulated by post-translational modifications such as sumoylation, phosphorylation, and polyubiquitination. Alternative splicing results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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