Thermo Fisher Scientific NGF Monoclonal Antibody (25623.1)
NGF 단백질을 표적으로 하는 Mouse IgG1 단일클론 항체. ELISA, 중화, 억제 분석에 적합. 인간 및 마우스 반응성. PBS 용액 형태, 단백질 A 정제, 보존제 없음. 단기 4°C, 장기 -20°C 보관 권장.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| ELISA (ELISA) | 2–8 µg/mL |
| Neutralization (Neu) | 0.1–0.4 µg/mL |
| Inhibition Assays (IA) | 0.1–0.4 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 25623.1 |
| Immunogen | Recombinant, full length human protein (NGF, UniProt ID: P01138-1, antigen range: 1–241) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A |
| Storage buffer | PBS |
| Contains | No preservative |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_795042 |
Product Specific Information
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Nerve growth factor (NGF) influences the survival and differentiation of various neuronal and non-neuronal cells. NGF binds to specific high- and low-affinity receptors on the cell surface; only the high-affinity receptor mediates signal transduction. Cross-linking studies with ¹²⁵I-NGF show that the high-affinity receptor in rat PC12 cells forms a 158 kDa complex with NGF, while the low-affinity receptor forms a 100 kDa complex. Full-length cDNA clones for human and rat NGF receptor genes show greater than 90% homology. NGF promotes nerve growth and differentiation of sympathetic and sensory neurons and is involved in their regulation. Mutations in the NGF gene are associated with hereditary sensory and autonomic neuropathy type 5 (HSAN5), and dysregulation of NGF expression is linked to allergic rhinitis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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