Thermo Fisher Scientific TGF beta-1 Monoclonal Antibody (9016.2)

Applications and Tested Dilutions

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Product Specifications

Product Specific Information

By ELISA, the antibody shows less than 5% cross-reactivity with TGF-beta 1.2 and less than 1% cross-reactivity with TGF beta 2, TGF beta 3, and TGF beta 5.

Target Information

TGF beta-1 (TGFB1, Transforming Growth Factor Beta 1) is a polypeptide member of the transforming growth factor beta superfamily of cytokines, found almost ubiquitously in tissues. Transforming growth factor (TGF)-β is stored in the extracellular matrix as a latent complex with its pro-domain. Activation of TGF beta-1 requires the binding of αV integrin to an RGD sequence in the prodomain and exertion of force on this domain, which is held in the extracellular matrix by latent TGF-β binding proteins. Latent forms are complexes of TGF beta-1, an amino-terminal portion of the TGF-beta precursor (TGF-LAP, latency associated peptide), and a specific binding protein (LTBP).
TGF beta-1 regulates proliferation, differentiation, adhesion, and migration in many cell types. Many cells have TGF beta receptors, and the protein regulates other growth factors positively and negatively. It is cleaved into a latency-associated peptide and a mature TGF beta-1 peptide, existing in either a latent or active form. The gene is often upregulated in tumor cells, and mutations can cause Camurati-Engelmann disease and cystic fibrosis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.