Thermo Fisher Scientific Caspase 12 Monoclonal Antibody (14F7)
Caspase-12 단백질을 특이적으로 인식하는 Rat monoclonal antibody(클론 14F7). Western blot, IHC, ICC/IF, IP 등 다양한 응용에 사용 가능. ER 스트레스 관련 apoptosis 연구에 적합. 2.2 mg/mL 농도의 액상형, 장기보관 시 -20°C 권장.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1–2 µg/mL | View 1 publication |
| Immunohistochemistry (IHC) | Assay-dependent | - |
| Immunocytochemistry (ICC/IF) | Assay-dependent | - |
| Immunoprecipitation (IP) | Assay-dependent | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse, Rat |
| Published Species | Human |
| Host / Isotype | Rat / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 14F7 |
| Immunogen | Recombinant fragment corresponding to residues 95–318 of mouse Caspase 12 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2.2 mg/mL |
| Purification | Purified |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 15 mM sodium azide |
| Storage Conditions | Store at 4°C (short term). For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_779522 |
Product Specific Information
Recommended positive control: NRK cells.
Target Information
Three distinct signaling pathways lead to programmed cell death (apoptosis):
- Death receptor pathway (involving caspase-8)
- Mitochondrial pathway (involving caspase-9)
- Endoplasmic reticulum (ER) stress pathway (involving caspase-12)
Caspase-12 is localized to the ER and activated by ER stress, such as disruption of ER calcium homeostasis, mediating ER stress-induced apoptosis. It co-localizes with proteins linked to Alzheimer’s disease, including γ-secretase presenilin and β-amyloid precursor protein (APP), and mediates amyloid-β-induced cytotoxicity. Caspase-12 is ubiquitously expressed in mouse tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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