Thermo Fisher Scientific Galectin 3 Monoclonal Antibody (eBioM3/38 (M3/38)), eBioscience
Galectin-3 단백질을 인식하는 Rat IgG2a 형 단클론 항체로, 인간 및 생쥐 시료에 반응합니다. Western blot, IHC, Flow Cytometry 등 다양한 응용에 적합하며, 고순도(>90%)로 정제된 액상 제품입니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 0.5 µg/mL | 7 |
| Immunohistochemistry (IHC) | - | 32 |
| Immunohistochemistry (Paraffin) (IHC-P) | Assay-Dependent | 3 |
| Immunohistochemistry (Frozen) (IHC-F) | Assay-Dependent | 1 |
| Immunocytochemistry (ICC/IF) | 1:100 | 4 |
| Flow Cytometry (Flow) | 0.25 µg/test | 3 |
| ELISA | Assay-Dependent | - |
| Immunoprecipitation (IP) | Assay-Dependent | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Human, Mouse, Rat |
| Host / Isotype | Rat / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | eBioM3/38 (M3/38) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_837131 |
Additional Formats
Product Specific Information
The eBioM3/38 antibody reacts with mouse Galectin-3 (Mac-2).
Galectins are a family of animal lectins with diverse biological functions. Galectin-3 (LGALS3, Mac-2, L-29) is a 30 kDa beta-galactoside-binding protein that binds IgE and mammalian cell surfaces when homodimerized or homo-oligomerized. It is expressed in epithelia, macrophages, dendritic cells, and Kupffer cells, and its expression increases during inflammation, proliferation, differentiation, and viral trans-activation.
This monoclonal antibody eBioM3/38 cross-reacts with human Galectin-3 (LGALS3).
Applications Reported:
Flow cytometry, immunoprecipitation, immunoblotting (WB), immunohistology (frozen and paraffin sections), and ELISA.
Applications Tested:
Tested by flow cytometric analysis of mouse PECs (thioglycollate-elicited peritoneal cells) at ≤0.25 µg/test.
A test corresponds to staining in 100 µL final volume (10⁵–10⁸ cells/test).
Optimization by titration is recommended.
Purity: >90% (SDS-PAGE)
Aggregation: <10% (HPLC)
Filtration: 0.2 µm post-manufacturing filtered
Target Information
Galectin-3 is a galactose-specific lectin that binds IgE and may mediate endothelial cell migration via integrin interactions. It cooperates with DMBT1 in epithelial cell differentiation during embryogenesis and acts as a pre-mRNA splicing factor in the nucleus. It is involved in acute inflammatory responses, including neutrophil activation, monocyte/macrophage chemoattraction, apoptotic cell opsonization, and mast cell activation.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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