Thermo Fisher Scientific NR4A1 Polyclonal Antibody
NR4A1(Nur77) 단백질을 인식하는 Rabbit Polyclonal Antibody. 인체 시료에 반응하며 IHC(P) 등 다양한 연구용 응용에 적합. 항원 친화 크로마토그래피로 정제된 액상 제품으로, 안정적인 장기 보관 가능.
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Applications
Tested Dilution
- Immunohistochemistry (Paraffin) (IHC (P)): 5 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic 16 amino acid peptide from N-terminal to DNA binding domain of human NUR77 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.4 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.1% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2551390 |
Product Specific Information
Percent identity with other species by BLAST analysis:
- Human (100%)
- Gorilla, Gibbon, Monkey (94%)
- Orangutan, Marmoset, Elephant (88%)
- Bovine, Panda, Horse (81%)
Target Information
NR4A1 is a member of the steroid-thyroid hormone-retinoid receptor superfamily. NGFI-B-alpha is expressed in brain, adrenal, thyroid, liver, testis, ovary, thymus, muscle, lung, and prostate. Its expression is induced in response to various stress stimuli and growth factors.
The encoded protein acts as a nuclear transcription factor involved in mediating apoptotic signaling in thymocytes and tumor cells, and plays a role in signaling in the hypothalamic-pituitary axis.
Translocation of the protein from the nucleus to mitochondria induces apoptosis.
Three transcript variants encoding two distinct isoforms have been identified for NR4A1. Variant (3), also known as TRC beta, contains multiple differences compared to variant 1. The resulting isoform b contains a shorter and distinct C-terminus compared to isoform a. RXR has been shown to be a partner for NR4A1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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