Thermo Fisher Scientific GPR120 Polyclonal Antibody

Applications

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1 µg/mL

Product Specifications

Product Specific Information

Percent identity with other species by BLAST analysis:

• Human, Gorilla, Gibbon, Monkey (100%)
• Marmoset (90%)
• Bovine (80%)

Target Information

An EST for GPR120 has been isolated from a human colon cancer library.
G-protein Coupled Receptors (GPCRs) comprise one of the largest families of signaling molecules with more than a thousand members currently predicted to exist.
All GPCRs share a structural motif consisting of seven membrane-spanning helices and exist in both active and inactive forms.
An array of activating ligands participate in the conformation of GPCRs leading to signaling via G-proteins and downstream effectors.
Ongoing studies have shown the vast series of reactions participating in the negative regulation of GPCRs. This “turn-off” activity has tremendous implications for physiological cellular action and continues to drive pharmacological research for new drug candidates.
Two GPCR-targeted blockbuster drugs, Zyprexa (Eli Lilly) and Claritin (Schering-Plough), dominate the mental health and allergy markets respectively.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.