Thermo Fisher Scientific GPR120 Polyclonal Antibody
GPR120 단백질을 인식하는 Rabbit Polyclonal 항체로, IHC(P) 실험에 적합합니다. Human 시료에 반응하며, 항원 친화 크로마토그래피로 정제되었습니다. PBS buffer에 0.1% sodium azide 포함, 4°C 단기 보관 및 -20°C 장기 보관 권장.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 2–4 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic 18 amino acid peptide from 3rd cytoplasmic domain of human O3FAR1 / GPR120 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.1% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2551394 |
Product Specific Information
- This antibody is not recommended for use in ICC applications.
- Percent identity with other species by BLAST analysis:
Human, Gorilla, Gibbon, Monkey, Bat, Elephant, Rabbit (94%)
Marmoset, Mouse, Rat, Pig (89%).
Target Information
An EST for GPR120 has been isolated from a human colon cancer library.
G-protein Coupled Receptors (GPCRs) comprise one of the largest families of signaling molecules with more than a thousand members predicted to exist. All GPCRs share a structural motif consisting of seven membrane-spanning helices and exist in both active and inactive forms.
Activating ligands induce conformational changes leading to signaling via G-proteins and downstream effectors. Studies have also revealed mechanisms for negative regulation of GPCRs, which are critical for cellular physiological control and pharmacological research.
Notably, GPCR-targeted pharmaceuticals such as Zyprexa (Eli Lilly) and Claritin (Schering-Plough) exemplify the therapeutic potential of this receptor family.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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