Thermo Fisher Scientific Chk1 Monoclonal Antibody (DCS-310)
Chk1 단백질을 표적하는 DCS-310 클론의 마우스 단클론 항체. Western blot, IHC, IP에 적합하며 인간, 마우스, 랫트 반응성. 단백질 A로 정제된 액상 항체로, 장기 보관 시 -20°C에서 보관 권장. DNA 손상 반응 연구에 유용.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1 µg/mL | View 2 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1 µg/mL | - |
| Immunoprecipitation (IP) | 2 µg / 0.2 mL of cell extract | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Human |
| Host / Isotype | Mouse / IgG3 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | DCS-310 |
| Immunogen | Recombinant full length protein (Human) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.2, with 0.2% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2080477 |
Product Specific Information
Heat in a microwave oven twice for 10 minutes in citrate buffer, pH 6.5.
Target Information
CHEK1 (CHK1) is a serine/threonine protein kinase involved in preventing replication when DNA integrity is compromised.
CHK1 is a key mediator in the DNA damage-induced checkpoint network and functions to ensure genomic integrity upon genotoxic stress.
When the G2 or S checkpoint is abrogated by inhibition of CHK1, p53-deficient cancer cells undergo mitotic catastrophe and apoptosis, while normal cells arrest in G1 phase.
Thus, CHK1 inhibitors can enhance the efficacy of DNA-damaging agents in cancer cells, making Chk1 an attractive therapeutic target, especially since approximately 50% of human cancers are p53-deficient.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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