Thermo Fisher Scientific p130 Monoclonal Antibody (DCS211.6)
인간 p130 단백질을 인식하는 Mouse 모노클로날 항체로, Western blot에 적합합니다. RBL2 단백질 연구용으로 사용되며, 세포 분열 및 크로마틴 구조 조절 연구에 유용합니다. 비결합형 액상 형태로 제공되며, 4°C 또는 -20°C에서 보관 가능합니다.
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Applications
- Western Blot (WB): 1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | DCS211.6 |
| Immunogen | Balb/c mice were immunized with human p130 protein and fusing the splenocytes with Sp2/0 mouse myeloma cells. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_1959154 |
Product Specific Information
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
RBL2 (also known as p130) or Retinoblastoma-like protein 2 is a key regulator of entry into cell division. It is directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation.
RBL2 recruits and targets histone methyltransferases KMT5B and KMT5C leading to epigenetic transcriptional repression. It controls histone H4 Lys20 trimethylation and likely acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters.
RBL2 serves as a potent inhibitor of E2F-mediated trans-activation and associates preferentially with E2F5.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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