Thermo Fisher Scientific Protein APC Monoclonal Antibody (FE9)

Applications

• Western Blot (WB)
  Tested Dilution: 1–1.5 µg/mL

Product Specifications

Product Specific Information

• Reacts with all full-length and truncated APC proteins.
• Successfully used in Western blot applications; expected band size ≈ 312 kDa.
• Suggested positive controls: HCT116 cells (p300) and SW480 cells (truncated APC, p147).

Target Information

This gene encodes a tumor suppressor protein that antagonizes the Wnt signaling pathway. It is also involved in cell migration, adhesion, transcriptional activation, and apoptosis.
Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that can progress to malignancy.
Disease-associated mutations are often clustered in the mutation cluster region (MCR), resulting in truncated protein products.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.