Thermo Fisher Scientific Protein APC Monoclonal Antibody (FE9)

Applications

Tested Dilution

Publications

Western Blot (WB)

1-1.5 µg/mL

-

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

FE9

Immunogen

synthetic peptide corresponding to the N-terminal 35 amino acid residues of APC. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:Protein APC,uniProtId:P25054-1,ncbiNodeId:9606,antigenRange:1,antigenLength:2843,antigenImageFileName:MA1-91039_Protein_APC_P25054-1_House_mouse.svg,antigenImageFileNamePDP:MA1-91039_Protein_APC_P25054-1_House_mouse_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.1 mg/mL

Purification

Protein G

Storage buffer

0.05M sodium phosphate, pH 7.5, with 0.2% gelatin

Contains

0.1% sodium azide

Storage conditions

4° C, do not freeze

Shipping conditions

Wet ice

RRID

AB_1954862

Product Specific Information

Reacts with all full length and truncated APC proteins.

MA1-91039 has been successfully used in Western blot applications, where a band of approximately 312 kDa is predicted to be detected. Suggested positive controls for this product are HCT116 cells for p300 and SW480 cells for truncated APC (p147).

Target Information

This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.