Thermo Fisher Scientific Estrogen Receptor alpha Monoclonal Antibody (SP1)
에스트로겐 수용체 알파(ERα)를 인식하는 토끼 단클론 항체로, IHC, WB, ICC 등 다양한 응용에 적합합니다. 인간 시료에 반응하며, 단백질 A로 정제된 액상형 제품입니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:25 | 27 publications |
| Immunohistochemistry (IHC) | - | 195 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200 | 22 publications |
| Immunocytochemistry (ICC/IF) | 1:25–1:250 | 6 publications |
| Flow Cytometry (Flow) | 1:200 | 1 publication |
| ChIP assay (ChIP) | 5 µL/10^6 cells | - |
| Dot blot (DB) | - | 1 publication |
| Miscellaneous PubMed (Misc) | - | 3 publications |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Human, Mouse, Rat, Sheep, Virus |
| Host / Isotype | Rabbit / IgG |
| Class | Monoclonal |
| Type | Antibody |
| Clone | SP1 |
| Immunogen | Synthetic peptide derived from C-terminus of human estrogen receptor alpha |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.014 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.2, with 1% BSA |
| Contains | 0.1% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10979688 |
Product Specific Information
- Predicted to react with porcine based on sequence homology.
- Heat-mediated antigen retrieval is recommended using 10 mM citrate buffer (pH 6.0) for 10 minutes, followed by cooling at room temperature for 20 minutes.
- After antigen retrieval, incubate samples with primary antibody for 30 minutes at room temperature.
- Suggested positive control: breast carcinoma.
Target Information
Estrogen Receptors (ER) belong to the steroid/thyroid hormone receptor superfamily of nuclear receptors. The estrogen receptor functions as a ligand-activated transcription factor that, upon binding to estrogen, undergoes a conformational change allowing dimerization and binding to estrogen response elements (ERE) in DNA. This interaction regulates gene transcription by recruiting coactivator or corepressor proteins.
There are two forms of estrogen receptors, alpha and beta, encoded by separate genes (ESR1 and ESR2). Alternative RNA splicing produces multiple isoforms of ER-alpha (66 kDa, 53 kDa, 47 kDa, and 35 kDa). Estrogen receptors are expressed in various tissues and are essential for sexual development, reproductive function, and bone metabolism. They are implicated in diseases such as breast cancer, endometrial cancer, and osteoporosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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