Thermo Fisher Scientific KAL1 Polyclonal Antibody
KAL1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, Western blot에 적합하며 Human, Mouse, Rat에 반응합니다. 항원 친화 크로마토그래피로 정제되었고, 고순도(>95%)를 제공합니다. 연구용으로만 사용 가능합니다.
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Applications
- Western Blot (WB): 1:500–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 205–250 of Human Anosmin |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term; for long-term storage, store at -20°C, avoiding freeze/thaw cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2719254 |
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen. The purity is >95% (by SDS-PAGE).
Target Information
KAL1 (Anosmin-1) is an extracellular matrix-associated glycosylated protein linked with Kallmann Syndrome (KS), an X-linked genetic disorder characterized by loss of smell due to abnormal olfactory bulb development and delayed puberty caused by disrupted migration of the gonadotropin-releasing hormone neuron.
Anosmin-1 directly binds FGFR1 via its N-terminal cysteine-rich domain, whey-acidic protein-like domain, and first FnIII repeat with the D2 and D3 ectodomains of FGFR1. It is thought that Anosmin-1 modulates FGFR1 signaling and affects the formation and activation of the FGF2-FGFR1-heparin complex.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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