Thermo Fisher Scientific GABRA4 Polyclonal Antibody
Rabbit Polyclonal Antibody recognizing human, mouse, and rat GABRA4 protein. Validated for Western blot (1:500–1:1,000). Affinity-purified with >95% purity. Supplied as liquid in PBS with 50% glycerol. For research use only.
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Applications
- Western Blot (WB): 1:500–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 123–168 of Human GABRA4 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.1% sodium azide |
| Storage conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2719242 |
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity chromatography using an epitope-specific immunogen. Purity is greater than 95% as determined by SDS-PAGE.
Target Information
Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian brain, acting at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines.
At least 16 distinct subunits of GABA-A receptors have been identified. The GABRA4 gene encodes the alpha-4 subunit, which has been implicated in the etiology of autism through interaction with the gamma-aminobutyric acid receptor beta-1 subunit. Alternatively spliced transcript variants encoding different isoforms have been observed.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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