Thermo Fisher Scientific USP13 Polyclonal Antibody
USP13 단백질을 인식하는 Rabbit Polyclonal 항체로 Western blot 및 IHC(P)에서 사용 가능. 다양한 종에 반응하며, 항원 친화 크로마토그래피로 정제됨. PBS/BSA 완충액에 보관되며, -20°C에서 냉동 보관 권장.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.25–1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 5–10 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Bovine, Dog, Horse, Human, Mouse, Non-human primate |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A portion of amino acids 500–550 of human USP13 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2540842 |
Target Information
Deubiquitinase that mediates deubiquitination of target proteins such as BECN1, MITF, SKP2 and USP10 and is involved in processes such as autophagy and endoplasmic reticulum-associated degradation (ERAD).
It participates in a regulatory loop controlling autophagy and p53/TP53 levels by stabilizing PIK3C3/VPS34-containing complexes through BECN1 deubiquitination.
Recruited by nuclear UFD1, it regulates ERAD via deubiquitination of SKP2 and UBL4A.
Also stabilizes SIAH2 independently of deubiquitinase activity.
Preferentially cleaves Lys-63-linked polyubiquitin chains and may cleave ISG15 in vitro.
[UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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