Thermo Fisher Scientific ST2 Polyclonal Antibody
Thermo Fisher Scientific ST2 Polyclonal Antibody는 인간 ST2 단백질(아미노산 25-65)을 면역원으로 제작된 토끼 IgG 폴리클로날 항체입니다. Western blot 및 IHC(F/P) 분석에 적합하며, IL-33 수용체 연구에 활용됩니다. 액상 형태로 제공되며, 4°C 또는 -20°C에서 안정적으로 보관 가능합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 4.0–5 µg/mL | View 1 publication |
| Immunohistochemistry (IHC) | – | View 2 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | 5 µg/mL | – |
| Immunohistochemistry (Frozen) (IHC (F)) | – | View 2 publications |
Product Specifications
| Specification | Description |
|---|---|
| Published Species | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A portion of amino acids 25–65 of human ST2 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.0 mg/mL |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2540840 |
Target Information
IL-33R, also known as ST2, is a receptor for IL-33 and a member of the IL-1 receptor family. Its extracellular domain consists of three Ig-like domains that interact with co-receptor IL-1RAcP and ligand IL-33. Upon IL-33 binding, the IL-33R complex associates with adaptor proteins MyD88, IRAK1, IRAK4, and TRAF6, activating NF-κB and MAPK pathways. This leads to the release of cytokines such as IL-5, IL-6, IL-8, and IL-13.
Two major isoforms exist:
- ST2L: membrane-bound form
- ST2S: soluble form acting as a decoy receptor
IL-33R is primarily expressed by mast cells, basophils, and eosinophils, and in mice, also by ILC2 and Th2 cells. Its signaling is implicated in immune conditions such as allergies, arthritis, atherosclerosis, and sepsis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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