Thermo Fisher Scientific Phospho-LIMK1/LIMK2 (Thr508, Thr505) Polyclonal Antibody
인산화된 LIMK1/LIMK2 (Thr508/Thr505)을 특이적으로 인식하는 Rabbit Polyclonal Antibody. Western blot, IHC, ICC/IF 등 다양한 응용 가능. 고순도 정제 및 안정적 액상 형태로 제공되며, 세포 신호전달 및 형태학 연구에 적합.
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific Phospho-LIMK1/LIMK2 (Thr508, Thr505) Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human LIMK1 (Accession P53667), corresponding to amino acid residues around phosphorylated Thr508. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816397 |
Product Specific Information
Antibody detects endogenous levels of LIMK1/2 only when phosphorylated at Threonine 508/505.
Target Information
Proteins containing LIM motifs are typically involved in cell fate determination and growth control. A family of proteins designated LIM kinases, including LIMK-1 and LIMK-2, has been identified.
LIMK-1 regulates F-actin stabilization and cofilin activity, playing a role in signaling pathways related to cell motility and morphogenesis. It inhibits neuronal differentiation of PC12 cells, likely by interfering with events downstream of MAPK activation.
Expression patterns of LIMK-1 and LIMK-2 suggest differing functions during development. A truncated form of LIMK-2 found in adult testis may arise from alternative exon initiation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.