Thermo Fisher Scientific Phospho-p130Cas (Tyr410) Polyclonal Antibody
p130Cas 단백질의 Tyr410 인산화 형태를 특이적으로 인식하는 rabbit polyclonal 항체. Western blot, IHC, ICC/IF에 사용 가능. Human, Mouse, Rat 반응성. 액상 형태로 PBS buffer(50% glycerol) 내 보관, -20°C 저장.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human BCAR1 (Accession P56945), corresponding to amino acid residues around phosphorylated Tyr410. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816403 |
Product Specific Information
Antibody detects endogenous levels of p130Cas only when phosphorylated at Tyrosine 410.
Target Information
The p130Cas (Cas for Crk-associated substrate) is a common cellular target of phosphorylation signals via v-Crk and v-Src oncoproteins. It has a unique structure containing a Src homology (SH)-3 domain followed by multiple YXXP motifs and a proline-rich region. p130Cas is implicated in various biological processes including cell adhesion, migration, growth factor stimulation, cytokine receptor engagement, and bacterial infection. Physiological functions include cardiovascular development, actin filament assembly, and Src-induced cell transformation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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