Thermo Fisher Scientific AKR1C3 Polyclonal Antibody
AKR1C3 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, IHC, ICC, IP 등 다양한 응용에 적합하며, Human 및 Rat 시료에 반응. 고순도 항원 친화 크로마토그래피 정제 및 안정한 PBS/glycerol buffer 제공.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:5,000–1:20,000 | View 3 publications |
| Immunohistochemistry (IHC) | – | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 | View 1 publication |
| Immunocytochemistry (ICC/IF) | 1:100–1:1,000 | – |
| Immunoprecipitation (IP) | 1:100–1:500 | – |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Rat |
| Published Species | Mouse, Pig |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to a region within amino acids 261–323 of Human AKR1C3 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 40% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2545541 |
Product Specific Information
- Recommended positive controls: HepG2, HeLa, AKR1C3 shRNA-transfected HeLa, rat liver
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
AKR1C3 is a member of the aldo/keto reductase superfamily, consisting of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols using NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity.
This enzyme catalyzes the reduction of prostaglandin (PG) D2, PGH2, and phenanthrenequinone (PQ), and the oxidation of 9-alpha,11-beta-PGF2 to PGD2. It may play an important role in the pathogenesis of allergic diseases such as asthma and may also have a role in controlling cell growth and/or differentiation. The AKR1C3 gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15–p14.
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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